Journal
NANOSCALE RESEARCH LETTERS
Volume 15, Issue 1, Pages -Publisher
SPRINGEROPEN
DOI: 10.1186/s11671-019-3241-2
Keywords
Extended-release; Local anesthetics; Nano-scale; Liposomes; Polymersome; Hybrid
Funding
- National Natural Science Foundation of China (NSFC) [81771205, 91632113]
- Natural Science Foundation of Shanghai [16JC1420500, 16JC1420502]
- Major Basic Research Program of Shanghai [16JC1420500, 16JC1420502]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2017-I2M-3-008]
Ask authors/readers for more resources
Extended-release local anesthetics (LAs) have drawn increasing attention with their promising role in improving analgesia and reducing adverse events of LAs. Nano-structured carriers such as liposomes and polymersomes optimally meet the demands of/for extended-release, and have been utilized in drug delivery over decades and showed satisfactory results with extended-release. Based on mature technology of liposomes, EXPAREL, the first approved liposomal LA loaded with bupivacaine, has seen its success in an extended-release form. At the same time, polymersomes has advances over liposomes with complementary profiles, which inspires the emergence of hybrid carriers. This article summarized the recent research successes on nano-structured extended-release LAs, of which liposomal and polymeric are mainstream systems. Furthermore, with continual optimization, drug delivery systems carry properties beyond simple transportation, such as specificity and responsiveness. In the near future, we may achieve targeted delivery and controlled-release properties to satisfy various analgesic requirements.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available