Journal
NANOSCALE RESEARCH LETTERS
Volume 15, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1186/s11671-019-3244-z
Keywords
Silver nanoparticles; Biosynthesis; Yeast Extract; Stability; Antibacterial activity
Funding
- National Natural Science Foundation of China [61971284, 61671299, 21171117]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning [GZ2016005]
- Center of Hydrogen Science at SJTU
- Startup Fund for Youngman Research at SJTU (SFYR at SJTU)
- Medical Engineering Crossover Fund of SJTU [YG2016MS26, YG2019QNA13]
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Biosynthesis for the preparation of antimicrobial silver nanoparticles (Ag NPs) is a green method without the use of cytotoxic reducing and surfactant agents. Herein, shape-controlled and well-dispersed Ag NPs were biosynthesized using yeast extract as reducing and capping agents. The synthesized Ag NPs exhibited a uniform spherical shape and fine size, with an average size of 13.8 nm. The biomolecules of reductive amino acids, alpha-linolenic acid, and carbohydrates in yeast extract have a significant role in the formation of Ag NPs, which was proved by the Fourier transform infrared spectroscopy analysis. In addition, amino acids on the surface of Ag NPs carry net negative charges which maximize the electrostatic repulsion interactions in alkaline solution, providing favorable stability for more than a year without precipitation. The Ag NPs in combination treatment with ampicillin reversed the resistance in ampicillin-resistant E. coli cells. These monodispersed Ag NPs could be a promising alternative for the disinfection of multidrug-resistant bacterial strains, and they showed negligible cytotoxicity and good biocompatibility toward Cos-7 cells.
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