Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 25, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.nano.2020.102171
Keywords
Magnetic hyperthermia; Cobalt ferrite nanoparticles; Temperature-dependent heating; Murine tumor models; Metastasis
Funding
- Ministry of Science and High Education of the Russian Federation in the framework of Increase Competitiveness Program of NUST MISiS [K2-2019-011]
- RFBR research project [17-00-00442]
- Russian Science Foundation [19-19-00626]
- RFBR [18-29-09061]
- Russian Science Foundation [19-19-00626] Funding Source: Russian Science Foundation
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Magnetic hyperthermia (MHT) is a promising approach for cancer therapy. However, a systematic MHT characterization as function of temperature on the therapeutic efficiency is barely analyzed. Here, we first perform comparative temperature-dependent analysis of the cobalt ferrite nanoparticles-mediated MHT effectiveness in two murine tumors models - breast (4T1) and colon (CT26) cancer in vitro and in vivo. The overall MHT killing capacity in vitro increased with the temperature and CT26 cells were more sensitive than 4T1 when heated to 43 degrees C. Well in line with the in vitro data, such heating cured non-metastatic CT26 tumors in vivo, while only inhibiting metastatic 4T1 tumor growth without improving the overall survival. High-temperature MHT (N47 degrees C) resulted in complete 4T1 primary tumor clearance, 25-40% long-term survival rates, and, importantly, more effective prevention of metastasis comparing to surgical extraction. Thus, the specific MHT temperature must be defined for each tumor individually to ensure a successful antitumor therapy. (c) 2020 Elsevier Inc. All rights reserved.
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