Journal
NANOMEDICINE
Volume 15, Issue 3, Pages 303-318Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2019-0308
Keywords
active targeting; cancer therapy; liposome; local stimulus-responsive liposomes; surface modification; targeted delivery
Funding
- Chinese University of Hong Kong
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In the development of cancer chemotherapy, besides the discovery of new anticancer drugs, a variety of nanocarrier systems for the delivery of previously developed and new chemotherapeutic drugs have currently been explored. Liposome is one of the most studied nanocarrier systems because of its biodegradability, simple preparation method, high efficacy and low toxicity. To make the best use of this vehicle, a number of multifunctionalized liposomal formulations have been investigated. The objective of this review is to summarize the current development of novel active targeting liposomal formulations, and to give insight into the challenges and future direction of the field. The recent studies in active targeting liposomes suggest the great potential of precise targeted anticancer drug delivery in cancer therapeutics. Graphical abstract
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