Journal
NANOMEDICINE
Volume 15, Issue 1, Pages 23-39Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2019-0166
Keywords
antioxidant enzyme; delivery of therapeutic; gold nanoparticle; immobilization; in vivo skin damage; silver nanoparticle; UV radiation
Funding
- NCN (National Center of Science, Poland) [2013/09/B/NZ7/01019]
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Aim: Superoxide dismutase (SOD) and catalase (CAT) immobilized on gold nanoparticles (AuNP) and silver nanoparticles (AgNP) nanoparticles were used to reduce UV radiation-induced oxidative stress in rat skin. Materials & methods: The antioxidant influence of the enzymes was investigated on level of malondialdehyde, 8-hydroksy-2 ' deoksyguanozine, myeloperoxidase, total antioxidant capacity, SOD2 and CAT activity and expression, and glutathione and glutathione peroxidase activity. Results: The application of immobilized SOD and CAT on UV-irradiated skin reduced malondialdehyde and 8-hydroksy-2 ' deoksyguanozine levels also SOD and CAT activity and expression increased. The tested enzymes influence glutathione peroxidase activity and level of total antioxidant capacity and glutathione. Conclusion: Immobilized enzymes increased the antioxidative potential of skin following UV irradiation.
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