Journal
NANO RESEARCH
Volume 13, Issue 2, Pages 373-379Publisher
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-020-2619-x
Keywords
mesoporous nanoparticle; tissue adhesive; wound repair; inflammation; accelerated healing
Categories
Funding
- National Natural Science Foundation of China [51732011, 21431006, 21761132008, 51471157, 21401183, 21771168]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [21521001]
- Key Research Program of Frontier Sciences, CAS [QYZDJ-SSW-SLH036]
- National Basic Research Program of China [2014CB931800]
- Users with Excellence and Scientific Research Grant of Hefei Science Center of CAS [2015HSC-UE007]
- Youth Innovation Promotion Association of CAS [2014298]
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Efficient initiation and resolution of inflammation are crucial for wound repair. However, with using tissue adhesives for wound repair, patients occasionally suffered from delayed healing process because slow elimination of those exogenous adhesives generally leads to chronic inflammation. As the demand for minimal invasive therapy continues to rise, desire for adhesive materials that can effectively reconnect surgical gaps and promote wound regeneration becomes increasingly urgent. Herein, by exploiting the inherent porous structure and performance of adhesion to tissue of mesoporous silica nanoparticles (MSNs), we demonstrate a tissue adhesive that can elicit acute inflammatory response and get eliminated after tissue reformation. With formation of nanocomposites in wound gaps, the injured tissues can get reconnected conveniently. The resultant accelerated healing process verify that the strategy of exploiting unique properties of nanomaterials can effectively promote inflammation resolution and wound repair. This design strategy will inspire more innovative tissue adhesives for clinical applications.
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