Journal
NANO LETTERS
Volume 20, Issue 3, Pages 1846-1854Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b05066
Keywords
dendrimer-Au nanoparticle network; hybrid membrane; ion selectivity; ionic current rectification; enhanced bioanalysis
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Funding
- National Natural Science Foundation of China [21874155, 21635004, 21575163]
- National Key Research and Development Program of China [2017YFA0206500]
- Natural Science Foundation of Jiangsu Province [BK20191316]
- Double First-Class University project [CPU2018GY25]
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Ion transport in an artificial asymmetric nanoporous membrane, which is similar to biological ion channels, can be used for biosensing. Here, a dendrimer-Au nanoparticle network (DAN) is in situ assembled on a nanoporous anodic aluminum oxide (AAO) surface, forming a DAN/AAO hybrid membrane. Benefiting from the high surface area and anion selectivity of DAN, the prepared DAN/AAO hybrid presents selective ion transport. Under a bias potential, a diode-like current-potential (I-V) response is observed. The obtained ionic current rectification (ICR) property can be tuned by the ion valence and pH value of the electrolyte. The rectified ionic current endows the as-prepared DAN/AAO hybrid with the ability of enhanced bioanalysis. Sensitive capture and detection of circulating tumor cells (CTCs) with a detection limit of 80 cells mL(-1 )as well as excellent reusability can be achieved.
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