Journal
NANO LETTERS
Volume 20, Issue 1, Pages 176-183Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b03556
Keywords
Semiconducting polymer nanoparticles; chemiluminescent imaging; chemodynamic therapy; monitoring catalytic activity
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Funding
- National Natural Science Foundation of China [21675043, 21890744, 51872088, 21804039, 51701022]
- Fundamental Research Funds for the Central Universities
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In chemodynamic therapy (CDT), real-time monitoring of reactive oxygen species (ROS) production is critical to reducing the nonspecific damage during CDT and feasibly evaluating the therapeutic response. However, CDT agents that can emit ROS-related signals are rare. Herein, we synthesize a semiconducting polymer nanoplatform (SPN) that can not only produce highly toxic ROS to kill cancer cells but also emit ROS-correlated chemiluminescent signals. Notably, the efficacy of both chemiluminescence and CDT can be significantly enhanced by hemin doping (similar to 10-fold enhancement for luminescent intensity). Such ROS-dependent chemiluminescence of SPN allows ROS generation within a tumor to be optically monitored during the CDT process. Importantly, SPN establishes an excellent correlation of chemiluminescence intensities with cancer inhibition rates in vitro and in vivo. Thus, our nanoplatform represents the first intelligent strategy that enables chemiluminescence-imaging-monitored CDT, which holds potential in assessing therapeutic responsivity and predicting treatment outcomes in early stages.
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