Journal
NANO LETTERS
Volume 20, Issue 2, Pages 1286-1295Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b04752
Keywords
peptide; morphology transformation; photothermal; drug delivery; photoacoustic
Categories
Funding
- National Natural Science Foundation of China [51725302, 21674027, 21704020, 31870998, 51573032]
- Fundamental Research Funds for the Central Universities [2662019YJ011]
Ask authors/readers for more resources
The in situ construction of the nanoassembly has been demonstrated to improve the performance of bioactive molecules, but the control of the morphology of nanomaterials in vivo still remains a tremendous challenge. Herein, a photothermal-promoted morphology transformation (PMT) strategy is developed to accelerate the formation of nanomaterials for improving the biological performance of drug molecules. Compared with the spontaneous process, the rate of transformation increases by similar to 4 times in the PMT process. Owing to increased assembly rate, the tumor accumulation of drugs is similar to 2-fold than that without photo irradiation, which inhibits tumor growth effectively. More importantly, the chemical reassembly process in vitro and in vivo is monitored by the advanced ratiometric photoacoustic image, confirming the photoinduced transformation acceleration. Through the noninvasively artificial control on assembly dynamics in vivo, the PMT strategy provides a new insight for developing the intelligent theranostics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available