Journal
MYCOSES
Volume 63, Issue 2, Pages 225-232Publisher
WILEY
DOI: 10.1111/myc.13030
Keywords
Candida albicans; cold atmospheric plasma; dielectric barrier discharge; fungus; non-thermal atmospheric plasma; onychomycosis; pulsed electric field; Trichophyton mentagrophytes
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Funding
- MOE Medical Devices, LLC
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Background Onychomycosis affects almost 6% of the world population. Topical azoles and systemic antifungal agents are of low efficacy and can have undesirable side effects. An effective, non-invasive therapy for onychomycosis is an unmet clinical need. Objective Determine the efficacy threshold of non-thermal atmospheric plasma (NTAP) to treat onychomycosis in an in vitro model. Methods A novel toe/nail-plate model using cadaver nails and agarose media inoculated with Candida albicans was exposed to a range of NTAP doses. Results Direct exposure of C albicans and Trichophyton mentagrophytes to 12 minutes of NTAP results in complete killing at doses of 39 and 15 kPulses, respectively. Onset of reduced viability of C albicans to NTAP treatment through the nail plate occurs at 64 kPulses with 10x and 100x reduction at 212 and 550 kPulses, respectively. Conclusions NTAP is an effective, non-invasive therapeutic approach to onychomycosis that should be evaluated in a clinical setting.
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