Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 26, Issue 5, Pages 554-560Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458519892491
Keywords
Multiple sclerosis; sex differences; neuroimaging; neuroimmunology; neurodegeneration; experimental autoimmune encephalomyelitis
Categories
Funding
- National Institutes of Health [RO1NS096748, RO1NS109670]
- Conrad N. Hilton Foundation [17734, 18394]
- Tom Sherak MS Hope Foundation
- Rhoda Goetz Foundation
- Sheri Safan fund
- Dunk MS Foundation
- Stephen Zamucen Fund
- Yvette and Eric Edidin Foundation
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Sex differences in the incidence or severity of disease characterize many autoimmune and neurodegenerative diseases. Multiple sclerosis is a complex disease with both autoimmune and neurodegenerative aspects and is characterized by sex differences in susceptibility and progression. Research in the study sex differences is a way to capitalize on a known clinical observation, mechanistically disentangle it at the laboratory bench, then translate basic research findings back to the clinic as a novel treatment trial tailored to optimally benefit each sex. This Bedside to Bench to Bedside approach based on sex differences in MS will be reviewed here, first for disease susceptibility then for disability progression.
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