Journal
MUCOSAL IMMUNOLOGY
Volume 13, Issue 3, Pages 413-422Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/s41385-020-0270-1
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Funding
- Cancer Research Institute/Fight CRC
- Bloombergsimilar toKimmel Institute for Cancer Immunotherapy
- Johns Hopkins School of Medicine and Department of Medicine
- Cancer Research UK's Grand Challenge Initiative
- NCI HTAN [U2CCA233291]
- Swim Across America
- National Institute of Health (National Cancer Institute) [K99 CA230192]
- National Institute of Health [R01 CA203891, R01 CA196845]
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The impact of the human microbiome on health and disease is of utmost importance and has been studied intensively in recent years. Microbes promote immune system development and are essential to the production and absorption of nutrients for the host but are also implicated in disease pathogenesis. Particularly, bacterial biofilms have long been recognized as contributors to chronic infections and diseases in humans. However, our understanding of how the host responds to the presence of biofilms, specifically the immune response to biofilms, and how this contributes to disease pathogenesis is limited. This review aims to highlight what is known about biofilm formation and in vivo models available for the biofilm study. We critique the contribution of biofilms to human diseases, focusing on the lung diseases, cystic fibrosis and chronic obstructive pulmonary disease, and the gut diseases, inflammatory bowel disease and colorectal cancer.
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