Journal
MOLECULES
Volume 24, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/molecules24244596
Keywords
Aspergillus sydowii; seawater-derived fungus; secondary metabolites; antimicrobial activity
Funding
- National Key Research and Development Program of China [2016YFD0501010]
- National Natural Science Foundation of China [31700043, 41506190, 81600672]
- Key Research and Development Program of Shandong Province [2019GSF107091]
- Major Agricultural Applied Technological Innovation Projects of Shandong Province
- Key Research and Development Plan of Yantai [2018XSCC045]
- Innovation Team Project for Modern Agricultural Industrious Technology System of Shandong Province [SDAIT-11-10]
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Marine-derived fungi are considered to be valuable producers of bioactive secondary metabolites used as lead compounds with medicinal importance. In this study, chemical investigation of the seawater-derived fungus Aspergillus sydowii SW9 led to the isolation and identification of one new quinazolinone alkaloid, 2-(4-hydroxybenzyl)-4-(3-acetyl)quinazolin-one (1), one new aromatic bisabolene-type sesquiterpenoid, (2) and one new chorismic acid analogue (3), as well as two known alkaloids (compounds 4 and 5). Their structures were determined by extensive 1D/2D NMR and mass spectrometric data, and the absolute configurations of 2 and 3 were assigned by the analysis of ECD spectra aided by quantum chemical computations. Compounds 1, 2, and 4 exhibited selective inhibitory activities against the human pathogenic bacteria Escherichia coli, Staphylococcus aureus, S. epidermidis, and Streptococcus pneumoniae, with MIC values ranging from 2.0 to 16 mu g/mL.
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