Journal
MOLECULES
Volume 24, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/molecules24244569
Keywords
puerarin; Pueraria candollei var; mirifica; ovariectomy; forced swimming test; tail suspension test; neurogenesis
Funding
- Institute of Natural Medicine, University of Toyama
- 2017 International Academic Exchange Program of University of Toyama
- Thailand Research fund (TRF)
- KKU [59211118]
- [UID/Multi/04423/2019]
- Fundação para a Ciência e a Tecnologia [UID/Multi/04423/2019] Funding Source: FCT
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Daily treatment of ovariectomized (OVX) ICR mice with puerarin, a glycosyl isoflavone isolated from the root bark of Pueraria candollei var. mirifica, and 17 beta-estradiol attenuated ovariectomy-induced depression-like behavior, as indicated by a decrease in immobility times in the tail suspension test (TST) and the forced swimming test (FST), an increase in the uterine weight and volume, a decrease in serum corticosterone levels, and dose-dependently normalized the downregulated transcription of the brain-derived neurotrophic factor (BDNF) and estrogen receptor (Er beta and Er alpha) mRNAs. Like 17 beta-estradiol, puerarin also inhibited ovariectomy-induced suppression of neurogenesis in the dentate gyrus of the hippocampus (increased the number of doublecortin (DCX)-immunosuppressive cells). These results suggest that puerarin exerts antidepressant-like effects in OVX animals, possibly by attenuating the OVX-induced hyperactivation of the HPA axis and/or normalizing the downregulated transcription of BDNF and ER mRNA in the brain.
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