Journal
MOLECULES
Volume 24, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/molecules24244527
Keywords
photochemistry; photodecarboxylation; phthalimide; continuous-flow photochemistry; multi-step synthesis; arylmethylene isoindolinones
Funding
- Australian Research Council (ARC) [DP130100794]
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An effective multi-step continuous flow approach towards N-diaminoalkylated 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones, including the local anesthetic compound AL-12, has been realized. Compared to the traditional decoupled batch processes, the combined photochemical-thermal-thermal flow setup rapidly provides the desired target compounds in superior yields and significantly shorter reaction times.
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