Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 64, Issue 5, Pages -Publisher
WILEY
DOI: 10.1002/mnfr.201900982
Keywords
d-allulose; inflammation; mRNA sequencing; pyrosequencing
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Funding
- National Research Foundation of Korea (NRF) - Korean government [NRF-2016R1A2B4011329]
- BK21 Plus Program (Department of Food Science AMP
- Nutrition, Kyungpook National University) - Ministry of Education (MOE, Korea) [22A20130000161]
- National Research Foundation of Korea (NRF)
- National Research Foundation of Korea [22A20130000161] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Scope The results of recent studies on d-allulose intervention in high-fat diet (HFD)-fed mice suggest that d-allulose has a substantial impact on obesity. In addition, several studies have uncovered bacterial candidates among the gut microbiota associated with obesity and inflammation in mice. To identify the d-allulose-attenuated genes related to the inflammation-associated bacterial candidates, two types of statistical analyses are performed. Methods and results Using liver and epididymal fat tissues, genes with expression levels that recovered from HFD-induced dysregulation are identified through differentially expressed gene (DEG) analysis. Finally, correlation-based network analysis between the diet, microbes, and the candidates identified from DEG analysis reveal 20 genes that showed anti-obesogenic patterns and associations with Lactobacillus and Coprococcus, which are representative bacterial candidates associated with inflammation and obesity. Conclusion The results of the present study suggest that d-allulose closely interacts with the candidate genes and microbes to alleviate weight gain and inflammation, partly via down regulation of Gm12250 expression in multiple tissues and increases the Lactobacillus and Coprococcus in gut microbiota composition.
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