Journal
MOLECULAR NEUROBIOLOGY
Volume 57, Issue 5, Pages 2220-2231Publisher
SPRINGER
DOI: 10.1007/s12035-020-01870-0
Keywords
Farnesylation; Geranylgeranylation; Mevalonate pathway inhibitors; Prenyl transferases; Ras superfamily; Rho; Ras; Rab subfamilies
Categories
Funding
- Texas Woman's University (TWU) Department of Biology
- National Science Foundation [DUE0806963, DUE 1154394]
- TWU Research Enhancement
- Center for Student Research Small Grants programs
- closing the Gaps
Ask authors/readers for more resources
Mevalonate pathway inhibitors have been extensively studied for their roles in cholesterol depletion and for inhibiting the prenylation and activation of various proteins. Inhibition of protein prenylation has potential therapeutic uses against neurological disorders, like neural cancers, neurodegeneration, and neurotramatic lesions. Protection against neurodegeneration and promotion of neuronal regeneration is regulated in large part by Ras superfamily small guanosine triphosphatases (GTPases), particularly the Ras, Rho, and Rab subfamilies. These proteins are prenylated to target them to cellular membranes. Prenylation can be specifically inhibited through altering the function of enzymes of the mevalonate pathway necessary for isoprenoid production and attachment to target proteins to elicit a variety of effects on neural cells. However, this approach does not address how prenylation affects a specific protein. This review focuses on the regulation of small GTPase prenylation, the different techniques to inhibit prenylation, and how this inhibition has affected neural cell processes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available