Journal
MOLECULAR MICROBIOLOGY
Volume 113, Issue 5, Pages 861-871Publisher
WILEY
DOI: 10.1111/mmi.14461
Keywords
folded protein; mechanism; protein transport; Tat pathway; twin-arginine signal peptide
Categories
Funding
- Medical Research Council [MR/S009213/1]
- Biotechnology and Biological Sciences Research council [BB/S005307/1, BB/N014545/1, BB/P01948X/1, BB/R002517/1, BB/S003339/1]
- Wellcome [110183/A/15/Z, 208361/Z/17/Z]
- BBSRC [BB/L000768/1, BB/N014545/1, BB/S005307/1, BB/P01948X/2, BB/N014545/2, BB/L001306/1, BB/P01948X/1, BB/S003339/1, BB/R002517/1] Funding Source: UKRI
- MRC [MR/S009213/1, G117/519, G0901653, G1001640] Funding Source: UKRI
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The twin-arginine protein transport (Tat pathway) is found in prokaryotes and plant organelles and transports folded proteins across membranes. Targeting of substrates to the Tat system is mediated by the presence of an N-terminal signal sequence containing a highly conserved twin-arginine motif. The Tat machinery comprises membrane proteins from the TatA and TatC families. Assembly of the Tat translocon is dynamic and is triggered by the interaction of a Tat substrate with the Tat receptor complex. This review will summarise recent advances in our understanding of Tat transport, focusing in particular on the roles played by Tat signal peptides in protein targeting and translocation.
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