Metal-free visible-light-mediated organophotoredox catalysis: synthesis of 3-functionalized indole via C-C, C-N bond formation

A visible-light-mediated, mild and one-pot three-component reaction in the presence of organophotoredox catalyst Eosin Y using EtOH:H2O as reaction medium for the synthesis of 3-functionalized indole derivatives was developed. Visible light used in the protocol is green, inexpensive, readily available energy source. The sustainable reagents make the protocol compatible with green chemistry demands. [GRAPHICS] .

Automated summary

A visible-light-mediated, one-pot three-component reaction using organophotoredox catalyst Eosin Y in EtOH:H2O was developed for the synthesis of 3-functionalized indole derivatives. The green light source used is inexpensive and sustainable, making the protocol compatible with green chemistry demands.