Journal
MOLECULAR CELL
Volume 77, Issue 4, Pages 688-708Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2019.12.021
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Funding
- NIH NIGMS [R35GM133557]
- Taub Family Foundation
- Azrieli Faculty Fellows program
- Israel Science Foundation [1479/18]
- Novartis Research Foundation
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation [759366]
- European Research Council (ERC) [759366] Funding Source: European Research Council (ERC)
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Rapidly developing technologies have recently fueled an exciting era of discovery in the field of chromosome structure and nuclear organization. In addition to chromosome conformation capture (3C) methods, new alternative techniques have emerged to study genome architecture and biological processes in the nucleus, often in single or living cells. This sets an unprecedented stage for exploring the mechanisms that link chromosome structure and biological function. Here we review popular as well as emerging approaches to study chromosome organization, focusing on the contribution of complementary methodologies to our understanding of structures revealed by 3C methods and their biological implications, and discuss the next technical and conceptual frontiers.
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