Journal
BIOSCIENCE REPORTS
Volume 35, Issue -, Pages -Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BSR20150014
Keywords
erythropoiesis; hepcidin; hypoxia; inflammation; iron
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Funding
- National Health and Medical Research Council (NHMRC) of Australia [APP10301325]
- NHMRC Senior Research Fellowship [APP1024672]
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Iron, an essential nutrient, is required for many diverse biological processes. The absence of a defined pathway to excrete excess iron makes it essential for the body to regulate the amount of iron absorbed; a deficiency could lead to iron deficiency and an excess to iron overload and associated disorders such as anaemia and haemochromatosis respectively. This regulation is mediated by the iron-regulatory hormone hepcidin. Hepcidin binds to the only known iron export protein, ferroportin (FPN), inducing its internalization and degradation, thus limiting the amount of iron released into the blood. The major factors that are implicated in hepcidin regulation include iron stores, hypoxia, inflammation and erythropoiesis. The present review summarizes our present knowledge about the molecular mechanisms and signalling pathways contributing to hepcidin regulation by these factors.
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