4.7 Review

The emerging role of SPOP protein in tumorigenesis and cancer therapy

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability

Lin-Gao Ju et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Oncology

Cancer statistics, 2019

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

Review Oncology

Glioma epigenetics: From subclassification to novel treatment options

Olga Gusyatiner et al.

SEMINARS IN CANCER BIOLOGY (2018)

Article Reproductive Biology

Uterine function in the mouse requires speckle-type poz protein

Lan Hai et al.

BIOLOGY OF REPRODUCTION (2018)

Article Oncology

Speckle-type POZ protein as a diagnostic biomarker in renal cell carcinoma

Ashutosh Chauhan et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2018)

Article Oncology

SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression

Jian Ma et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Article Reproductive Biology

Establishment and molecular characterization of a human ovarian clear cell carcinoma cell line (FDOV1)

Wei Jiang et al.

JOURNAL OF OVARIAN RESEARCH (2018)

Article Biochemistry & Molecular Biology

SPOP promotes FADD degradation and inhibits NF-κB activity in non small cell lung cancer

Jie Luo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

Jill J. Bouchard et al.

MOLECULAR CELL (2018)

Article Biotechnology & Applied Microbiology

miRNA-543 promotes cell migration and invasion by targeting SPOP in gastric cancer

Junfei Xu et al.

ONCOTARGETS AND THERAPY (2018)

Article Oncology

The genetic landscape of endometrial clear cell carcinomas

Deborah F. DeLair et al.

JOURNAL OF PATHOLOGY (2017)

Article Biochemistry & Molecular Biology

Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

Xiangpeng Dai et al.

NATURE MEDICINE (2017)

Article Multidisciplinary Sciences

Inherited determinants of early recurrent somatic mutations in prostate cancer

Alessandro Romanel et al.

NATURE COMMUNICATIONS (2017)

Article Oncology

Cancer Statistics, 2017

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2017)

Article Biochemistry & Molecular Biology

SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth

Jie Luo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Chemistry, Medicinal

Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors

Pradeep S. Jadhavar et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Article Oncology

TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer

Anna C. Groner et al.

CANCER CELL (2016)

Article Oncology

Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer

Zhong-Qiang Guo et al.

CANCER CELL (2016)

Article Biochemistry & Molecular Biology

Liquid-liquid phase separation in cellular signaling systems

P. Andrew Chong et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles

Melissa R. Marzahn et al.

EMBO JOURNAL (2016)

Article Urology & Nephrology

Genetic Progression of High Grade Prostatic Intraepithelial Neoplasia to Prostate Cancer

Seung-Hyun Jung et al.

EUROPEAN UROLOGY (2016)

Review Cell Biology

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

Lori Buetow et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Obstetrics & Gynecology

SPOP Regulates Endometrial Stromal Cell Decidualization in Mice

Na Liu et al.

REPRODUCTIVE SCIENCES (2016)

Article Oncology

Cancer Statistics, 2015

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2015)

Article Medicine, Research & Experimental

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia

Frances-Rose Schumacher et al.

EMBO MOLECULAR MEDICINE (2015)

Article Pathology

Expression and significance of cortactin and HDAC6 in human prostatic foamy gland carcinoma

Huilian Hou et al.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2015)

Article Gastroenterology & Hepatology

Properties and Clinical Relevance of Speckle-Type POZ Protein in Human Colorectal Cancer

Junfei Xu et al.

JOURNAL OF GASTROINTESTINAL SURGERY (2015)

Review Endocrinology & Metabolism

Progesterone action in breast, uterine, and ovarian cancers

Caroline H. Diep et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2015)

Review Genetics & Heredity

Histone deacetylase 6 in health and disease

Carole Seidel et al.

EPIGENOMICS (2015)

Article Oncology

Decreased expression of the SPOP gene is associated with poor prognosis in glioma

Dacheng Ding et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

Article Oncology

Breast Cancer Statistics, 2013

Carol DeSantis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2014)

Article Oncology

Colorectal cancer statistics, 2014

Rebecca Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2014)

Review Medical Laboratory Technology

The Emerging Genomic Landscape of Endometrial Cancer

Matthieu Le Gallo et al.

CLINICAL CHEMISTRY (2014)

Article Oncology

Clinico-pathological significance of the molecular alterations of the SPOP gene in prostate cancer

Maria Garcia-Flores et al.

EUROPEAN JOURNAL OF CANCER (2014)

Article Biology

Differential expression of speckled POZ protein, SPOP: Putative regulation by miR-145

Chiu-Jung Huang et al.

JOURNAL OF BIOSCIENCES (2014)

Article Oncology

SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer

Chunyan Zeng et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2014)

Review Biotechnology & Applied Microbiology

SCF ubiquitin ligase-targeted therapies

Jeffrey R. Skaar et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Review Biochemistry & Molecular Biology

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

John C. Christianson et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

Jean-Philippe P. Theurillat et al.

SCIENCE (2014)

Review Oncology

Roles of F-box proteins in cancer

Zhiwei Wang et al.

NATURE REVIEWS CANCER (2014)

Article Biochemical Research Methods

Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP

Laura K. van Geersdaele et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2013)

Review Biochemistry & Molecular Biology

The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications

Pascal Genschik et al.

EMBO JOURNAL (2013)

Review Cell Biology

The mechanisms of Hedgehog signalling and its roles in development and disease

James Briscoe et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

Chuandong Geng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Oncology

Molecular pathogenesis and mechanisms of thyroid cancer

Mingzhao Xing

NATURE REVIEWS CANCER (2013)

Review Oncology

Regulatory networks defining EMT during cancer initiation and progression

Bram De Craene et al.

NATURE REVIEWS CANCER (2013)

Review Oncology

Antiprogestins in breast cancer treatment: are we ready?

Claudia Lanari et al.

ENDOCRINE-RELATED CANCER (2012)

Article Genetics & Heredity

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

Christopher E. Barbieri et al.

NATURE GENETICS (2012)

Article Medicine, General & Internal

Common Musculoskeletal Tumors of Childhood and Adolescence

Carola A. S. Arndt et al.

MAYO CLINIC PROCEEDINGS (2012)

Article Biochemistry & Molecular Biology

Adaptor Protein Self-Assembly Drives the Control of a Cullin-RING Ubiquitin Ligase

Wesley J. Errington et al.

STRUCTURE (2012)

Review Cell Biology

Gli Proteins in Development and Disease

Chi-chung Hui et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

Article Biochemistry & Molecular Biology

Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex

Bogyou Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Editorial Material Oncology

Disruptive Events in the Life of Prostate Cancer

J. Chad Brenner et al.

CANCER CELL (2011)

Review Biotechnology & Applied Microbiology

The Role of HDAC6 in Cancer

Grace I. Aldana-Masangkay et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2011)

Article Multidisciplinary Sciences

The genomic complexity of primary human prostate cancer

Michael F. Berger et al.

NATURE (2011)

Review Biotechnology & Applied Microbiology

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets

Lynn Bedford et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Review Cell Biology

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

Allan M. Weissman et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

Article Oncology

Follicular Adenoma and Carcinoma of the Thyroid Gland

Christopher R. McHenry et al.

ONCOLOGIST (2011)

Review Pathology

Mammalian Sirtuins: Biological Insights and Disease Relevance

Marcia C. Haigis et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Article Medicine, Research & Experimental

Pcif1 modulates Pdxl protein stability and pancreatic β cell function and survival in mice

Kathryn C. Claiborn et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Multidisciplinary Sciences

Diverse somatic mutation patterns and pathway alterations in human cancers

Zhengyan Kan et al.

NATURE (2010)

Review Pharmacology & Pharmacy

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

Shin-ichiro Imai et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2010)

Review Biochemistry & Molecular Biology

RING Domain E3 Ubiquitin Ligases

Raymond J. Deshaies et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

Article Multidisciplinary Sciences

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6

Angela Gibbs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Cell Biology

Hedgehog Signaling in Development and Cancer

Jin Jiang et al.

DEVELOPMENTAL CELL (2008)

Review Cell Biology

Diversity of degradation signals in the ubiquitin-proteasome system

Tommer Ravid et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

BTB/POZ domain of speckle-type POZ protein (SPOP) confers proapoptotic function in HeLa cells

Boohyeong Byun et al.

BIOFACTORS (2007)

Review Genetics & Heredity

Opinion - Inherited epigenetic variation - revisiting soft inheritance

EJ Richards

NATURE REVIEWS GENETICS (2006)

Review Oncology

Pathogenetic mechanisms in thyroid follicular-cell neoplasia

T Kondo et al.

NATURE REVIEWS CANCER (2006)

Article Multidisciplinary Sciences

Phosphorylated FADD induces NF-κB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas

GA Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

JJ Kovacs et al.

MOLECULAR CELL (2005)

Review Cell Biology

Function and regulation of Cullin-RING ubiquitin ligases

MD Petroski et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Letter Cell Biology

Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases

M Furukawa et al.

NATURE CELL BIOLOGY (2003)

Article Genetics & Heredity

Basal cell carcinomas in mice overexpressing Gli2 in skin

M Grachtchouk et al.

NATURE GENETICS (2000)