Journal
MITOCHONDRION
Volume 50, Issue -, Pages 121-131Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2019.10.003
Keywords
Mitochondria; Proteostasis; Quality control; Proteases; Chaperones; Mitophagy; Aggregates
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Funding
- Swedish Research Council
- Knut and Alice Wallenberg Foundation
- Austrian Science Fund FWF [P27183-B24]
- Austrian Science Fund (FWF) [P27183] Funding Source: Austrian Science Fund (FWF)
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Mitochondria play pivotal roles in cellular energy metabolism, the synthesis of essential biomolecules and the regulation of cell death and aging. The proper folding, unfolding and degradation of the many proteins active within mitochondria is surveyed by the mitochondrial quality control machineries. Here, we describe the principal components of the mitochondrial quality control system and recent developments in the elucidation of the molecular mechanisms maintaining a functional mitochondrial proteome.
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