Journal
MICROCHIMICA ACTA
Volume 187, Issue 2, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-019-4064-7
Keywords
Electrochemical sensor; Nanocomposite; Enzyme-free; Carbon nanotubes; Protein based biopolymers; Cancer detection
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Funding
- Shiraz University Research Council
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A nanobiocomposite was prepared from multiwalled carbon nanotubes and zein nanoparticles. It was dispersed in water/ethanol and drop cast onto a glassy carbon electrode. The modified electrode can be used for electroreduction of H2O2 (typically at a working potential of -0.71 V vs. Ag/AgCl). The electrochemical properties of the electrode were investigated by cyclic voltammetry, linear sweep voltammetry, chronoamperometry and electrochemical impedance spectroscopy. Response to H2O2 is linear in the 0.049 to 22 mu M concentration range, and the detection limit is 35 nM at pH 7.0. The sensor was successfully utilized for the measurement of H2O2 in a synthetic urine sample, and for monitoring the release of H2O2 from human dermal fibroblasts and human hepatocellular carcinoma cells. Graphical abstract Schematic representation of a novel metal- and enzyme-free electrochemical nanosensor. A glassy carbon electrode was modified with a nanocomposite prepared from multiwalled carbon nanotubes and zein nanoparticles. It was applied to the identification of liver cancer cells via sensing of H2O2 and has a very low detection limit.
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