Journal
MICROBIOLOGY
Volume 88, Issue 6, Pages 769-772Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0026261719060067
Keywords
T5 bacteriophage; O-antigen; enterobacteria; phage therapy
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Funding
- Russian Foundation for Basic Research [18-29-08015]
- Russian Science Foundation [DT57C/DT571/2]
- [15-15-00134P]
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The T5 group bacteriophages, which infect a number of enterobacterial species and strains, are useful objects for obtaining therapeutic phage preparations with broad specificity. The present work considers the biological properties of T5-related phages responsible for their ability to infect a broad spectrum of bacterial strains in spite of a limited number of known phage receptor proteins. Ability of bacteriophages to recognize bacterial O-antigens specifically enhances their capacity for infection and increases the therapeutic potential of the T5 phages.
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