Journal
METABOLIC BRAIN DISEASE
Volume 35, Issue 3, Pages 517-525Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11011-019-00526-w
Keywords
Neurodegeneration; Bacopa monnieri; Cytokines; ROS; Parkinson's disease
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Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of dopaminergic neurons in substantia nigra region and the presence of alpha-synuclein aggregates in the striatum and surrounding areas of brain. Evidences suggest that neuroinflammation plays a role in the progression of PD. We examined the neuro-protective effects of Bacopa monnieri (BM) in regulating neuroinflammation. Administration of BM suppressed the level of pro-inflammatory cytokines, decreased the levels of alpha-synuclein, and reduced reactive oxygen species (ROS) generation in PD animal model. Pre-treatment of BM showed more prominent results as compare to co- and post-treatment. Results suggest that Bacopa can limit inflammation in the different areas of brain, thus, offers a promising source of novel therapeutics for the treatment of many CNS disorders.
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