Journal
CALCIFIED TISSUE INTERNATIONAL
Volume 99, Issue 1, Pages 1-12Publisher
SPRINGER
DOI: 10.1007/s00223-016-0122-x
Keywords
miRNAs; Autophagy; Osteoporosis; Mechanism
Categories
Funding
- Natural Science Foundation of China [81503591]
- Science and Technology Projects of Guangdong Province [2014A020221021]
- Natural Science Foundation of Guangdong Province [2014A030310082]
- Guangzhou University of Chinese Medicine for excellent Young Scholars Project [KAB110133K04]
- Disciplinary Construction Fund of Education Department in Guangdong Province [2013LYM-0012]
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Imbalances between bone formation and resorption are the primary cause of osteoporosis. However, currently, a detailed molecular mechanism of osteoporosis is not available. Autophagy is the conserved process characterized by degrading and recycling aggregated proteins, intracellular pathogens, and damaged organelles. MicroRNAs (miRNAs) are novel regulatory factors that play important roles in numerous cellular processes, including autophagy, through the posttranscriptional regulation of gene expression. Conversely, autophagy plays a role in the regulation of miRNA homeostasis. Recent advances have revealed that both autophagy and miRNAs are involved in the maintenance of bone homoeostasis, whereas the role of the interaction of miRNAs with autophagy in osteoporosis remains unclear. In this paper, we review previous reports on autophagy, miRNAs, and their interaction in osteoporosis.
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