Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 105, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2019.110129
Keywords
Layer-by-layer assembly; Gum Arabic; O-carboxymethyl chitosan; Intestine-targeted delivery; Pharmacokinetics
Categories
Funding
- National Science Foundation of China [31571890]
- Key R&D Project (Medical Foods) of Shandong Province [2018YYSP013]
- Major Fundamental Research Project of Shandong Province [ZR2018ZC0945]
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The intestine-targeted delivery performance of the gum Arabic (GA) - O-carboxymethyl chitosan (OCMC) microcapsules prepared by layer-by-layer (LbL) assembly and genipin crosslinking was evaluated by using an acid-susceptible compound omeprazole as the model. Confocal laser scanning microscope observation revealed that spherical microcapsules with the core-shell structure were successful fabricated. Genipin crosslinking did not affect the microencapsulation yield or drug load, but significantly decreased the particle size and positive charge of the microcapsules, and increased their stability against disintegration in the simulated gastric fluid. Pharmacokinetic analysis indicated that entrapment by GA - OCMC LbL assembly greatly improved the bioavailability of omeprazole and crosslinking by 0.1 mg/mL genipin led to the highest value of 8.76 relative to the control formulation. It was concluded that the GA - OCMC LbL microcapsules could be used for the oral delivery of nutraceuticals and its delivery performance could be tailored by varying the genipin crosslinking degree.
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