Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 107, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2019.110311
Keywords
Eggshell membrane; Thermoplastic polyurethane; Endothelialization; Antithrombogenicity; Small-diameter vascular graft
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Funding
- NHLBI of the National Institutes of Health [U01HL134655]
- Kuo K. and Cindy F. Wang Professorship at the University of Wisconsin-Madison
- Office of the Vice Chancellor for Research and Graduate Education at the University of Wisconsin-Madison
- National Center for International Research of Micro-Nano Molding Technology at Zhengzhou University
- International Science & Technology Cooperation Program of China [2015DFA30550]
- China Scholarship Council [201707040014]
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In this study, a small-diameter, double-layered eggshell membrane/thermoplastic polyurethane (ESM/TPU) vascular graft with a wavy structure was developed. The avian eggshell membrane, a fibrous structure similar to the extracellular matrix (ECM), has the potential to yield rapid endothelialization in vitro. The dopamine and heparin modification of the ESM surface not only promoted human umbilical vein endothelial cell (HUVEC) proliferation via cytocompatibility assessment, but also improved its anticoagulation properties as verified in platelet adhesion tests. The biomimetic mechanical properties of the vascular graft were provided by the elastic TPU fibers via electrospinning using a wavy cross-section rotating collector. The advantage of combining these two materials is to make use of the bioactivity of ESM as the internal membrane and the tunable mechanical properties of TPU as the external layer. The circumferentially wavy structure of the vascular graft produced a toe region in the non-linear section of the stress strain curve similar to that of natural blood vessels. The ESM/TPU graft's circumferential ultimate strength was 2.57 MPa, its strain was 339% mm/mm, and its toe region was found to be around 20% mm/mm. Cyclical tension tests showed that the vascular graft could maintain good mechanical properties and showed no structural damage under repeated extension tests.
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