Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 107, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2019.110256
Keywords
Flower-like porous carbon; Surface modification; Microwave-triggered; pH-triggered; Drug release
Categories
Funding
- National Natural Science Foundation of China [21071115]
- Key Laboratory of Seenriched Products Development and Quality Control (Ministry of Agriculture), National and Local Joint Engineering Laboratory for Selenium-enriched Food Development [Se-2018806]
- Key Science and Technology Innovation Team of Shaanxi Province [2019TD-007]
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In this work, ZnO capped flower-like porous carbon-Fe3O4 composite (FPCS-Fe3O4-ZnO) was constructed as a carrier for pH and microwave bi-triggered drug delivery. In the composite, the FPCS achieves high-efficiency drug loading, the Fe3O4 acts as magnetic targeting agent and microwave absorption enhancer, and the ZnO nanoparticle as a sealing agent in response to pH stimulation. The carrier exhibited a flower-mesoporous sphere of 270 um, a specific surface area of 101 m(2)/g, a saturation magnetization of 14.08 emu/g, as well as good microwave thermal conversion properties (The temperature was raised from 25 degrees C to 60 degrees C only 24 s). Simultaneously, the carrier achieved an efficient drug loading with a drug loading rate of 99.1%. During the drug release experiments, obvious pH-dependent release behavior was observed, the drug release rate at 12 h was 8.2%, 19.0%, and 56.3% at pH 7.4, 5.0 and 3.0 respectively. Moreover the drug release rate increased from 8.2% to 39.9% after microwave stimulation at pH 7.4. In addition, cytotoxicity tests indicate that the carrier has good biocompatibility. Thus, this multifunctional pH and microwave bi-triggered carrier was expected to be further applied to drug delivery system(DDS).
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