Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 79, Issue 8, Pages 1366-1368Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09168451.2015.1018125
Keywords
iron deficiency; heart; oxidative stress; autophagy; antioxidant enzyme
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Funding
- Japan Society for the Promotion of Science (JSPS) [25750057]
- Grants-in-Aid for Scientific Research [25750057, 25450181] Funding Source: KAKEN
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We investigated the effects of dietary iron deficiency on the redox system in the heart. Dietary iron deficiency increased heart weight and accumulation of carbonylated proteins. However, expression levels of heme oxygenase-1 and LC3-II, an antioxidant enzyme and an autophagic marker, respectively, in iron-deficient mice were upregulated compared to the control group, resulting in a surrogate phenomenon against oxidative stress.
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