Journal
MATERIALS CHEMISTRY AND PHYSICS
Volume 239, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2019.122117
Keywords
Freeze-drying method; Spray-drying method; Inclusion complex; UV-Vis absorption
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Funding
- Brazilian agency CAPES, Brazil
- Brazilian agency CNPq, Brazil
- Brazilian agency Fundacao Arauctiria, Brazil
- Brazilian agency FINEP, Brazil
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The Inclusion complex of Nystatin (NYS) with beta-cyclodextiin (beta-CD) can increase the solubility of the antibiotic in aqueous media. The complexes were obtained by freeze-drying (FD) and spray-drying (SD) methods. The spectroscopic techniques used to analyze the complexes were FT-Raman, photoacoustic spectroscopy (PAS), and H-1 NMR. FT-Raman allowed the identification of the interactions of beta-CD with NYS molecule through the vibrational modes assigned to tetraene, heptaene and C=O. PAS confirms that the main part of interaction from NYS Is heptaene. The H-1 NMR showed that the hydrogens inside the cavity of beta-CD interact with NYS. These techniques confirmed the complex formation and that the drying method affects the form of complexation: by the FD method one molecule of beta-CD is sufficient to form the complex with NYS. In contrast, the inclusion complex of NYS: beta-CD by the SD method is formed by two molecules of beta-CD. These results showed the effectiveness of these techniques in evaluating the inclusion complex and demonstrate that the drying method affects how this complexation occurs.
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