Journal
MATERIALS CHEMISTRY AND PHYSICS
Volume 239, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2019.121968
Keywords
Porous scaffolds; Voronoi tessellation; SLM; Stress shielding; Young's modulus
Categories
Funding
- Advanced Research Project of Army Equipment Development [301020803]
- Key Research and Development Program of Jiangsu [BE 2015161]
- Jiangsu Provincial Research Foundation for Basic Research, China [BK 20161476]
- Science and Technology Planning Project of Jiangsu Province of China [BE 2015029]
- Science and Technology Support Program of Jiangsu [BE 2016010-3]
- Nanjing University of Aeronautics and Astronautics major project cultivation plan [NP2017414]
- Nanjing University of Aeronautics and Astronautics Youth Technology Innovation Fund [NT2018016]
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The use of irregular porous structures in bone tissue engineering (BTE) has attracted increasing attention. An irregular porous structure is similar to that of human bone tissue and is more suitable for bone tissue growth than a regular porous structure. In this study, we propose a top-down design method for constructing irregular porous structures based on Voronoi tessellation. The model constructed with this method was fabricated by selective laser melting (SLM) and industrial computed tomography (CT) was used to measure the morphological characteristics; the mechanical properties were obtained by quasi-static compressive test. The experimental results showed that the samples had a porosity ranging from 50% to 85%, an average pore diameter ranging from 512 to 998 mu m, an apparent elastic modulus ranging from 2.13 to 3.97 Gpa, and a compressive strength ranging from 78.99 to 130.5 Mpa and met the artificial implant requirements. Three regression equations were established between the three design parameters and the porosity, apparent elastic modulus, and compressive strength using a response surface methodology (RSM). The equations allow for better control of the irregular porous structure and the prediction of the properties.
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