Journal
MARINE DRUGS
Volume 18, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/md18020114
Keywords
tetramic acid; bioactivity; marine natural product; marine-derived microorganisms
Categories
Funding
- National Natural Science Foundation of China [41806155]
- Guangdong MEPP Fund [GDOE (2019) A21]
- Special Fund for Economic Development of Guangdong Province (Uses for Marine Economic Development) [GDME-2018C004]
- Natural Science Foundation of Guangdong Province [2018A030310304]
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Tetramic acid (pyrrolidine-2,4-dione) compounds, isolated from a variety of marine and terrestrial organisms, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities. In the past decade, marine-derived microorganisms have become great repositories of novel tetramic acids. Here, we discuss the biological activities of 277 tetramic acids of eight classifications (simple 3-acyl tetramic acids, 3-oligoenoyltetramic acids, 3-decalinoyltetramic acid, 3-spirotetramic acids, macrocyclic tetramic acids, N-acylated tetramic acids, alpha-cyclopiazonic acid-type tetramic acids, and other tetramic acids) from marine-derived microbes, including fungi, actinobacteria, bacteria, and cyanobacteria, as reported in 195 research studies up to 2019.
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