Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 84, Issue 2, Pages 686-697Publisher
WILEY
DOI: 10.1002/mrm.28151
Keywords
atherosclerosis; carotid artery; magnetic resonance imaging; quantitative susceptibility mapping (QSM); USPIO; water-fat separation
Funding
- Medical Research Council/Sackler Stipend
- Addenbrooke's Charitable Trust
- National Institute for Health Research [Cambridge Biomedical Research Centre (BRC) at the Cambridge University Hospitals NHS Foundation Trust]
- Mountbatten Cambridge International Scholarship
- Cambridge Trust
- Christ's College
- Sir Ernest Cassel Educational Trust
- NIHR Cambridge BRC
Ask authors/readers for more resources
Purpose Imaging carotid artery plaques to identify features of vulnerability typically requires a multicontrast MRI protocol. The identification of regions of inflammation with ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles requires separate pre- and postcontrast scans. We propose a method of joint water-fat separation and quantitative susceptibility mapping (QSM) to aid classification of atherosclerotic plaques and offer a positive contrast mechanism in USPIO-imaging. Methods Ten healthy volunteers (3 women and 7 men; aged, 30.7 +/- 10.7 years) were imaged at 1.5T to develop an acquisition and postprocessing protocol. Five patients (1 woman and 4 men; mean age, 71 +/- 7.5 years) with moderate to severe luminal stenosis were imaged pre- and postadministration of a USPIO contrast agent. We used a multiecho gradient echo acquisition to perform water/fat separation and subsequently QSM. The results were compared with a conventional multicontrast MRI protocol, CT images, and histopathology data. Results In the volunteer scans, a multiecho gradient echo acquisition with bipolar readout gradients demonstrated to be a reliable acquisition methodology to produce high-quality susceptibility maps in conjunction with the proposed postprocessing methodology. In the patient study, water/fat separation provided a tool to identify lipid-rich necrotic cores and QSM provided a qualitative and quantitative evaluation of plaque features and positive contrast when evaluating USPIO uptake. Plaque calcification could be identified by strong diamagnetism (-1.27 +/- 0.71 ppm), while USPIO uptake demonstrated a strong paramagnetism (1.32 +/- 0.61 ppm). Conclusion QSM was able to identify multiple plaque features in a single acquisition, providing positive contrast for plaques demonstrating USPIO uptake and negative contrast for calcification.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available