4.2 Article

Measurement of the hydrodynamic radii of PEE-G dendrons by diffusion spectroscopy on a benchtop NMR spectrometer

Journal

MAGNETIC RESONANCE IN CHEMISTRY
Volume 58, Issue 7, Pages 641-647

Publisher

WILEY
DOI: 10.1002/mrc.4997

Keywords

benchtop NMR; dendrimer; DOSY; hydrodynamic radius

Funding

  1. College of the Ozarks

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Benchtop nuclear magnetic resonance (NMR) spectroscopy is a useful tool for the rapid determination of the self-diffusion coefficient and the hydrodynamic radius of dendrons. The self-diffusion coefficients of the first four generations of poly ethoxy ethyl glycinamide (PEE-G) dendrons are measured by diffusion-ordered spectroscopy (DOSY) on a benchtop NMR equipped with diffusion gradient coils. The hydrodynamic radii of the dendrons are calculated via the Stokes-Einstein equation. The effects of solvent and pH are determined with the hydrodynamic radius increasing with generation and decreasing upon neutralization of an acidic solution. These measurements provide valuable information for biological and pharmaceutical applications of dendrons.

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