Journal
LIVER INTERNATIONAL
Volume 40, Issue 4, Pages 860-865Publisher
WILEY
DOI: 10.1111/liv.14377
Keywords
microbiome; microbiota; virulence factors
Categories
Funding
- Marga und Walter Boll-Stiftung [210-03-2016]
- Koln Fortune
- University of Cologne [160/2014]
- NIH [R01 AA24726, U01 AA026939]
- NIDDK [P30 DK120515]
- DFG [LA 4286/1-1]
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Several studies show associations between gut bacterial dysbiosis and chronic liver diseases, but causative mechanisms are largely unclear. We recently identified cytolysin, a bacterial exotoxin expressed and secreted by Enterococcus faecalis to cause liver damage in the setting of alcohol-related liver disease. Cytolysin was increased and highly correlated with liver disease severity and mortality in alcoholic hepatitis patients. In this study, we investigated if faecal cytolysin-positivity can be linked to non-alcoholic fatty liver disease, a highly prevalent disease where new biomarkers and treatment targets are urgently needed. In contrast to what we observed in alcoholic hepatitis, only seven out of 96 non-alcoholic fatty liver disease patients were cytolysin-positive, and these patients did not have increased liver disease activity compared with cytolysin-negative patients. These results indicate that the association of cytolysin carriage with worse clinical outcome might be specific for alcoholic hepatitis.
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