Short-Time Administration of Xanthone From Garcinia mangostana Fruit Pericarp Attenuates the Hepatotoxicity and Renotoxicity of Type II Diabetes Mice

Objective: Our previous studies reported that xanthone can protect from hyperglycemia-induced diabetes mellitus (DM) via possessing antioxidant activity. An attempt has been made to evaluate the protective effect of xanthone against hepatotoxicity and renotoxicity of high-fat-diet and single-dose-streptozotocin-induced DM mice. Method: In this research, in vitro antioxidant and antidiabetic assays were performed. In vivo oral glucose and maltose tolerance test, metabolic parameters, plasma biochemical markers, oxidative status, etc. were evaluated in experimental mice. In addition, liver/kidney tissue histology and kidney apoptosis were observed using hematoxylin and eosin staining and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays, respectively. Results: Xanthone exhibited potent in vitro antioxidant and antidiabetic activity. Xanthone treatments to diabetic mice significantly (p < 0.05) improved the biochemical and antioxidant parameters compared to that of the control group. Moreover, xanthone treatments also significantly (p < 0.05) reformed the liver and kidney histological alterations as well as reduced the cellular apoptosis of kidney tissue. Conclusions: All findings together concluded that xanthone could be a dietary supplement for the patient with diabetic complications.