Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 142, Issue 1, Pages 327-334Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b10770
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Funding
- 3M
- Alfred P. Sloan Foundation
- Research Corporation for Science Advancement (RCSA)
- National Institutes of Health (NIH) [R35GM124746]
- UCLA Graduate Division
- NSF Division of Materials Research Grant [1506886]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1506886] Funding Source: National Science Foundation
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For decades, chemists have strived to mimic the intricate design and diverse functions of naturally occurring systems through the bioinspired synthesis of programmable inorganic nanomaterials. The development of thiol-capped gold nanoparticles (AuNPs) has driven advancement in this area; however, although versatile and readily accessible, hybrid AuNPs are rarely atomically precise, which limits control over their surface topology and therefore the study of complex structure-function relationships. Here, we present a bottom-up approach to the systematic assembly of atomically precise hybrid nanoclusters employing a strategy that mimics the synthetic ease with which thiol-capped AuNPs are normally constructed, while producing well-defined covalent nanoscale assemblies with diverse surface topologies. For the first time, using a structurally characterized cluster-based organometallic building block, we demonstrate the systematic synthesis of nanoclusters with multivalent binding capabilities to complex protein targets.
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