4.8 Article

An Organometallic Strategy for Assembling Atomically Precise Hybrid Nanomaterials

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 142, Issue 1, Pages 327-334

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b10770

Keywords

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Funding

  1. 3M
  2. Alfred P. Sloan Foundation
  3. Research Corporation for Science Advancement (RCSA)
  4. National Institutes of Health (NIH) [R35GM124746]
  5. UCLA Graduate Division
  6. NSF Division of Materials Research Grant [1506886]
  7. Direct For Mathematical & Physical Scien
  8. Division Of Materials Research [1506886] Funding Source: National Science Foundation

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For decades, chemists have strived to mimic the intricate design and diverse functions of naturally occurring systems through the bioinspired synthesis of programmable inorganic nanomaterials. The development of thiol-capped gold nanoparticles (AuNPs) has driven advancement in this area; however, although versatile and readily accessible, hybrid AuNPs are rarely atomically precise, which limits control over their surface topology and therefore the study of complex structure-function relationships. Here, we present a bottom-up approach to the systematic assembly of atomically precise hybrid nanoclusters employing a strategy that mimics the synthetic ease with which thiol-capped AuNPs are normally constructed, while producing well-defined covalent nanoscale assemblies with diverse surface topologies. For the first time, using a structurally characterized cluster-based organometallic building block, we demonstrate the systematic synthesis of nanoclusters with multivalent binding capabilities to complex protein targets.

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