Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 142, Issue 8, Pages 3675-3679Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b12882
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Funding
- Peking-Tsinghua Center for Life Sciences, Beijing National Laboratory for Molecular Sciences
- National Science Foundation of China [31521004, 21672011, 21822101]
- National Key Research and Development Program of China [2017YFA0104003]
- High-Performance Computing Platform of Peking University
- PKUAIC
- College of Chemistry and Molecular Engineering, Peking University
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An enantioselective total synthesis of (-)-batrachotoxinin A is accomplished based on a key photoredox coupling reaction and the subsequent local-desymmetrization operation. After the expedient assembly of the highly oxidized steroid skeleton, a delicate sequence of redox manipulations was carried out to deliver a late-stage intermediate on gram scale-and ultimately (-)-batrachotoxinin A in an efficient manner.
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