Journal
JOURNAL OF SUPERCRITICAL FLUIDS
Volume 155, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.supflu.2019.104651
Keywords
Supercritical phase inversion; Supercritical CO2; Laponite; Cellulose acetate; Membranes; Cells adhesion
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Funding
- Ministerio de Educacion y Formacion Profesional, Spain [CAS18/0060]
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Supercritical phase inversion was used to prepare new polymeric membranes, based on cellulose acetate and Laponite (R), for tissue engineering applications. These composite membranes were characterized by a porous structure (porosity around 85%) with an average pore size ranging from about 9 to 13 mu m depending on the initial weight ratio cellulose acetate/Laponite. This ratio also controlled thermal and mechanical properties of these membranes: Laponite modified membrane decomposition step and increased the membrane elasticity modulus up to 4 MPa while decreasing the percentage elongation at break from 240% to 180%. Laponite also increased material cells adhesion: thanks to its homogeneous inclusion into the membranes, a remarkable cells adhesion of around 80%, six times higher than the original material, was obtained. (C) 2019 Elsevier B.V. All rights reserved.
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