Journal
JOURNAL OF SEPARATION SCIENCE
Volume 43, Issue 9-10, Pages 1678-1727Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.202000011
Keywords
1D chromatography; 2D chromatography; chemometrics; data processing; optimization
Categories
Funding
- Nederlandse Organisatie voor Wetenschap-pelijk Onderzoek
- Agilent Technologies [4354]
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The proliferation of increasingly more sophisticated analytical separation systems, often incorporating increasingly more powerful detection techniques, such as high-resolution mass spectrometry, causes an urgent need for highly efficient data-analysis and optimization strategies. This is especially true for comprehensive two-dimensional chromatography applied to the separation of very complex samples. In this contribution, the requirement for chemometric tools is explained and the latest developments in approaches for (pre-)processing and analyzing data arising from one- and two-dimensional chromatography systems are reviewed. The final part of this review focuses on the application of chemometrics for method development and optimization.
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