Journal
JOURNAL OF POROUS MATERIALS
Volume 27, Issue 2, Pages 555-562Publisher
SPRINGER
DOI: 10.1007/s10934-019-00837-4
Keywords
Mesoporous silica; Cs microspheres; Drug delivery
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Mesoporous silica nanoparticles (MSNs) were prepared using sol-gel method. Chitosan-MSNs microspheres scaffold loaded with ciprofloxacin also prepared via an ionotropic gelation method. The prepared samples were characterized using FE-SEM, TEM, FTIR and XRD analysis. The pore volume and mean pore diameter for MSNs was determined by the Brunauer-Emmett-Teller (BET) method. The in vitro drug test was evaluated by using UV-Vis spectrophotometry at lambda(max) of 275 nm. The estimated (measured) MSNs pore volume and pore diameter were 0.9227 cm(3)/g and 2.6058 nm, respectively. The Chitosan-MSNs loaded with ciprofloxacin show a spherical surface with good and uniform distribution of the MSNs in the microspheres. The in vitro drug release confirms that the MSNs containing beads shows a retarding release (approximate to 90% in 9 h) than beads without MSNs (approximate to 90% in 2 h). In the light of these findings, the developed delivery system scaffold holds great potential for bone regeneration by control drug release used in activation osteoblast cells.
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