4.2 Article

Parameters of Blood Flow in Great Arteries in Hypertensive ISIAH Rats with Stress-Dependent Arterial Hypertension

Journal

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 161, Issue 4, Pages 468-471

Publisher

SPRINGER
DOI: 10.1007/s10517-016-3440-0

Keywords

arterial hypertension; ISIAH rats; magnetic resonance angiography; volumetric blood flow rate; vascular resistance

Funding

  1. Russian Science Foundation [14-35-00020, 14-15-00118]
  2. Russian Science Foundation [14-35-00020] Funding Source: Russian Science Foundation

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Magnetic resonance angiography was used to examine blood flow in great arteries of hypertensive ISIAH and normotensive Wistar rats. In hypertensive ISIAH rats, increased vascular resistance in the basin of the abdominal aorta and renal arteries as well as reduced fraction of total renal blood flow were found. In contrast, blood flow through both carotid arteries in ISIAH rats was enhanced, which in suggests more intensive blood supply to brain regulatory centers providing enhanced stress reactivity of these rats characterized by stress-dependent arterial hypertension.

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