Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 161, Issue 2, Pages 296-299Publisher
SPRINGER
DOI: 10.1007/s10517-016-3399-x
Keywords
ultrasound; nanoparticles; tumor; sonodynamic therapy
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Funding
- Russian Science Foundation [14-50-00029]
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The possibility of using mesoporous silicon nanoparticles as amplifiers (sensitizers) of therapeutic ultrasonic exposure were studied experimentally in vitro and in vivo. The combination of nanoparticles and ultrasound led to a significant inhibition of Hep-2 cancer cell proliferation and Lewis lung carcinoma growth in mice. These results indicated good prospects of using silicon nanoparticles as sensitizers for sonodynamic therapy of tumors.
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