Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 162, Issue 1, Pages 27-29Publisher
SPRINGER
DOI: 10.1007/s10517-016-3536-6
Keywords
heart; ischemia; reperfusion; postconditioning
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Funding
- Russian Science Foundation [14-15-00008]
- Russian Science Foundation [14-15-00008] Funding Source: Russian Science Foundation
- British Heart Foundation [PG/15/66/31710] Funding Source: researchfish
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CB receptor agonist HU-210 exhibits an infarction-limiting effect during in vitro reperfusion of the heart after focal ischemia. This effect is paralleled by a decrease in left-ventricular developed pressure and double product. In addition, HU-210 reduces end-diastolic pressure during the reperfusion period, which indirectly attests to reduced Ca2+ overload of cardiomyocytes.
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