Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 124, Issue 6, Pages 1065-1070Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcb.9b10987
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Funding
- National Institutes of Health [R35-GM130326]
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Hydrogen bonds between protein side-chain hydroxyl (OH) and phosphate groups are one of the most common types of intermolecular hydrogen bonds in protein-DNA/RNA complexes. Using NMR spectroscopy, we identified and characterized the hydrogen bonds between tyrosine side-chain OH and DNA phosphate groups in a protein-DNA complex. These OH groups exhibited relatively slow hydrogen-exchange rates and sizable scalar couplings between hydroxyl H-1 and DNA phosphate P-31 nuclei across the hydrogen bonds. Information about intermolecular hydrogen bonds facilitates investigations of the DNA/RNA recognition by the protein.
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