Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 161, Issue 6, Pages 821-825Publisher
SPRINGER
DOI: 10.1007/s10517-016-3520-1
Keywords
poliovirus receptor; oncolytic viruses; malignant gliomas; poliovirus; virotherapy
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Funding
- Russian Science Foundation [14-14-00882]
- Russian Science Foundation [14-14-00882] Funding Source: Russian Science Foundation
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A humanized line of rat C6 glioma cells expressing human poliovirus receptor was obtained and tested for the sensitivity to oncolytic effects of vaccine strains of type 1, 2, and 3 polioviruses. Presentation of the poliovirus receptor on the surface of C6 glioma cells was shown to be a necessary condition for the interaction of cells with polioviruses, but insufficient for complete poliovirus oncolysis.
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