Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 160, Issue 5, Pages 653-655Publisher
SPRINGER
DOI: 10.1007/s10517-016-3241-5
Keywords
neuropeptide cycloprolylglycine; cerebroprotective activity; neuroprotective activity; incomplete global cerebral ischemia; glutamate neurotoxicity
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Funding
- Russian Foundation for Basic Research [15-04-04485]
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We studied cerebroprotective properties of neuropeptide cycloprolylglycine (1 mg/kg) administered intraperitoneally to rats with modeled incomplete global ischemia rats and neuroprotective properties for HT-22 cells under conditions of glutamate toxicity. It was shown that the neuropeptide administered during the postischemic period restored the neurological status of rats by preventing sensorimotor impairments in the limb-placing test and suppression of locomotor activity in the open field test. In in vitro experiments, cycloprolylglycine in concentrations of 10(-5)-10(-8) M exhibited pronounced dose-dependent neuroprotective activity. The results attest to high cerebro- and neuroprotective potential of endogenous peptide cycloprolylglycine.
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