Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 160, Issue 6, Pages 767-770Publisher
SPRINGER
DOI: 10.1007/s10517-016-3305-6
Keywords
cellulose sulfate; anticoagulant; aIIa activity; aXa activity
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Funding
- Federal Targeted Program for Research and Development in Priority Areas of Development of the Russian Scientific and Technological Complex [RFME-FI60714X0031]
- Presidium of Russian Academy of Sciences Fundamental Sciences for Medicine
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Experiments on rabbits showed that increasing the dose of intravenously administered cellulose sulfate from wheat straw (dynamic viscosity 3.4 cP, sulfur content 14.1%) increased plasma clotting time in some coagulation tests and plasma anticoagulant activity. When cellulose sulfate was administered in the dose of 1 mg/kg, plasma clotting time in the presence of the anticoagulant (5 min after administration) was similar to 3-fold higher than after saline administration.
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